History

This project evolved from an earlier Genome Canada Applied Human Health (AHH) project entitled “Mass Spectrometer-based Flow Cytometer, Methods and Applications”. Led by Dr. John E. Dick at the University Health Network, the AHH project lasted from 2005 to early 2008.

The purpose of the AHH project was to develop a technology for personalized therapeutic diagnosis and prognosis. The effort concentrated on:

Developing a Phase 0 prototype instrument that addresses a real diagnostic challenge
Developing metal-containing affinity reagents for use with the instrument
Demonstrating how diagnostic and prognostic assessment of leukemia could be transformed

The current Genome Canada Technology Development project, entitled "Massively Multiparametric Mass Cytometer Analyzer", is led by Dr. Scott D. Tanner and is based at the University of Toronto. It is focused on pre-commercial development of the mass cytometer and reagents.

Please click here to go to the AHH project website.

This project is funded by Genome Canada through the Ontario Genomics Institute:

Ontario Genomics Institute - The Future is in Our Genes.

Complementary funding is gratefully acknowledged from:

: DVS Sciences

: Ministry of Research and Innovation

News & Events

Raising the Bar: The Royal Society of Chemistry has published an interview with Scott Tanner.

Click here to find out about upcoming and past events.

Publications

Bandura DR, Baranov VI, Ornatsky OI, Antonov A, Kinach R, Lou X, Pavlov S, Vorobiev S, Dick JE, Tanner SD. Mass Cytometry: Technique for Real Time Single Cell Multitarget Immunoassay based on Inductively Coupled Plasma Time-of-Flight Mass-Spectrometry. Analytical Chemistry, 2009, 81 (16), pp 6813–6822.
Tanner SD, Bandura DR, Ornatsky O, Baranov VI, Nitz M, Winnik MA. Flow Cytometer with mass spectrometer detection for massively multiplexed single-cell biomarker assay. Pure and Applied Chemistry 2008 Dec 1; 80(12): 2627-2641.
Ornatsky OI, Lou X, Nitz M, Schäfer S, Sheldrick WS, Baranov VI, Bandura DR, Tanner SD. Study of cell antigens and intracellular DNA by identification of element-containing labels and metallointercalators using inductively coupled plasma mass spectrometry. Anal Chem. 2008 Apr 1;80(7):2539-47. Epub 2008 Mar 5.

Click here for more publications.