| |
“If cancer stem cells lie at the heart of some cancers, then being able to predict the behavior of tumors and providing effective therapies against them means understanding the abnormal growth pathways within the stem cells themselves.”
- John Dick, Project Leader (UHN)
“The only reason that I'm willing to take a risk on this project is my confidence in the quality and camaraderie of my colleagues.”
- Scott Tanner, Principal Investigator (University of Toronto)
“We're examining DNA not for its well-recognized role as the genetic material to store and transmit genetic information, but rather for its less-known potential to act as a novel cancer diagnostic tool.”
- Yingfu Li, Principal Investigator (McMaster University)
“We're gaining more understanding of cell defects and how to modify them, so that treatment is no longer a shotgun approach, but more like an arrow aimed at a specific target.”
- Mark Minden, Principal Investigator (OCI)
| |
McKenzie JL, Gan OI, Doedens M, Dick JE. Reversible cell surface expression of CD38 on CD34-positive human hematopoietic repopulating cells, Exp Hematol. 2007 Sep;35(9):1429-36.
Barabe F, Kennedy JA, Hope KJ, Dick JE. Modeling the initiation and progression of human acute leukemia in mice, Science. 2007 Apr 27;316(5824):600-4.
McKenzie JL, Takenaka K, Gan OI, Doedens M, Dick JE. Low Rhodamine123 retention identifies long-term human hematopoietic stem cells within the Lin-CD34+CD38- population, Blood. 2007 Jan 15;109(2):543-5.
O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice, Nature. 2007 Jan 4;445(7123):106-10.
Kennedy JA, Barabe F, Patterson BJ, Barber DL, Dick JE. Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo, Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):16930-5.
McKenzie JL, Gan OI, Doedens M, Wang JC, Dick JE. Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment, Nat Immunol. 2006 Nov;7(11):1225-1233.
Jin L, Hope KJ, Zhai Q, Smadja-Joffe F, Dick JE. Targeting of CD44 eradicates human acute myeloid leukemic stem cells, Nat Med. 2006 Oct;12(10):1167-74.
Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. Cancer Stem Cells--Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells, Cancer Res. 2006 Oct 1;66(19):9339-44.
Dick JE, Lapidot T. Biology of normal and acute myeloid leukemia stem cells, Int J Hematol. 2005 Dec;82(5):389-96.
Wang JC, Warner JK, Erdmann N, Lansdorp PM, Harrington L, Dick JE. Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cells, Proc Natl Acad Sci USA. 2005 Oct 4;102(40):14398-403.
Warner JK, Wang JCY, Takenaka K, Doulatov S, McKenzie JL, Harrington L, Dick JE. Direct evidence for cooperating genetic events in the leukemic transformation of normal human hematopoietic cells, Leukemia. 2005 Oct; 19 (10):1794-805.
Wang JCY, Dick JE. Cancer stem cells: lessons from leukemia, Trends in Cell Biology. 2005 Sep; 15 (9): 494-501.
McKenzie JL, Gan OI, Doedens M, Dick JE. Human short-term repopulating stem cells are efficiently detected following intra-femoral transplantation into NOD/SCID recipients depleted of CD122+ cells, Blood. 2005 Aug 15; 106(4): 1259-61.
Hope KJ, Jin L, Dick JE. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity, Nat Immunol. 2004 Jul;5(7):738-43.
Warner JK, Wang JC, Hope KJ, Jin L, Dick JE. Concepts of human leukemic development, Oncogene. 2004 Sep 20;23(43):7164-77.
Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell, Nat Med. 1997 Jul;3(7):730-7.
Larochelle A, Vormoor J, Hanenberg H, Wang JC, Bhatia M, Lapidot T, Moritz T, Murdoch B, Xiao XL, Kato I, Williams DA, Dick JE. Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy, Nat Med. 1996 Dec;2(12):1329-37.
Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA, Dick JE, A cell initiating human acute myeloid leukaemia after transplantation into SCID mice, Nature. 1994 Feb 17;367(6464):645-8.
|
